GENEVA--(BUSINESS WIRE)--Regulatory News:
GeNeuro (Paris:GNRO) (Euronext Paris: CH0308403085 - GNRO), a biopharmaceutical company developing new treatments for neurodegenerative and autoimmune diseases such as multiple sclerosis (MS), amyotrophic lateral sclerosis (ALS) and the severe neuropsychiatric consequences of COVID-19 (post-COVID), announced today the publication in the leading scientific journal "Annals of Neurology" of the results of the collaboration between GeNeuro and the National Institute of Neurological Disorders and Stroke (NINDS). NINDS is part of the National Institutes of Health (NIH) of the United States. This publication describes the novel pathogenic mechanism of HERV-K in sporadic ALS and confirms the action of GeNeuro's antibody to neutralize this toxicity.
The online publication (HERV-K envelope in spinal fluid of Amyotrophic Lateral Sclerosis is toxic - Steiner et al, - Annals of Neurology) presents preclinical data showing that HERV-K Envelope protein leads to neuronal cell injury and death as part of an extracellular release of the HERV-K ENV protein, and identifies the cellular receptor targeted by this endogenous toxin. The study also shows that the neurotoxic properties of the HERV-K ENV protein, detected in the cerebrospinal fluid of ALS patients, are neutralized by GeNeuro’s anti-HERV-K ENV antibody.
Dr. Hervé Perron, Scientific Director of GeNeuro, said: "This publication highlights the results obtained through the collaboration between NINDS and GeNeuro. It underlines the relevance of GeNeuro's approach to sporadic ALS via its novel monoclonal antibody that inhibits the neurotoxic effects of the HERV-K ENV protein, an endogenous toxin detected in the cerebrospinal fluid of patients. We now want to move forward as quickly as possible to provide what could be a treatment that changes the prospects for patients".
As previously mentioned, GeNeuro's preclinical development program has enabled its anti-HERV-K ENV antibody to be humanized and ready to enter GMP production. GeNeuro continues to be in active discussions with potential partners for the clinical development of the humanized antibody GNK301.
Amyotrophic lateral sclerosis (ALS), often referred to as Lou Gehrig’s disease, is a rapidly progressing neurodegenerative disorder characterized by the destruction of motor neurons leading to progressive muscle paralysis. ALS affects approximately 50,000 patients worldwide, with about 10,000 new patients per year in the United States and Europe.
About GeNeuro
GeNeuro‘s mission is to develop safe and effective treatments against neurological disorders and autoimmune diseases, such as multiple sclerosis, by neutralizing causal factors encoded by HERVs, which represent 8% of human DNA.
GeNeuro is based in Geneva, Switzerland and has R&D facilities in Lyon, France. It owns rights to 17 patent families protecting its technology.
For more information, visit: www.geneuro.com
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Disclaimer:
This press release contains certain forward - looking statements and estimates concerning GeNeuro’s financial condition, operating results, strategy, projects and future performance and the markets in which it operates. Such forward-looking statements and estimates may be identified by words, such as “anticipate,” “believe,” “can,” “could,” “estimate,” “expect,” “intend,” “is designed to,” “may,” “might,” “plan,” “potential,” “predict,” “objective,” “should,” or the negative of these and similar expressions. They incorporate all topics that are not historical facts. Forward looking statements, forecasts and estimates are based on management’s current assumptions and assessment of risks, uncertainties and other factors, known and unknown, which were deemed to be reasonable at the time they were made but which may turn out to be incorrect. Events and outcomes are difficult to predict and depend on factors beyond the company’s control. Consequently, the actual results, financial condition, performances and/or achievements of GeNeuro or of the industry may turn out to differ materially from the future results, performances or achievements expressed or implied by these statements, forecasts and estimates. Owing to these uncertainties, no representation is made as to the correctness or fairness of these forward-looking statements, forecasts and estimates. Furthermore, forward-looking statements, forecasts and estimates speak only as of the date on which they are made, and GeNeuro undertakes no obligation to update or revise any of them, whether as a result of new information, future events or otherwise, except as required by law.
