-

Circle Pharma Appoints Constantine Kreatsoulas, PhD as its Vice President, Research Informatics and Computational Chemistry

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Constantine Kreatsoulas, PhD has joined Circle Pharma as its Vice President of Research Informatics and Computational Chemistry.

Dr. Kreatsoulas joins Circle from GlaxoSmithKline (GSK) where he was the Head of US Molecular Design and Interim Head of Computational Toxicology. His responsibilities at GSK included leading structure-based drug design (SBDD) teams and the development of informatics tools for quantitative experimental data analytics and drug hazard identification. Previously he was a Research Fellow at Merck & Co., Inc., where he focused on SBDD, molecular modeling, machine learning, and small molecule safety assessment and a postdoctoral fellow at Bristol-Meyers Squibb focused on machine learning in predictive toxicology. Dr. Kreatsoulas was awarded a doctorate in chemistry from Princeton University, holds a master’s degree in regulatory affairs and quality assurance from Temple University and received a BA in mathematics and chemistry from New York University.

“We are delighted to welcome Constantine to the Circle team,” said Raj Singh, PhD, Circle’s Chief Scientific Officer. “Constantine brings over two decades of experience spanning molecular modeling and design for early drug discovery through development, high performance scientific computing, and toxicology modeling. We are excited to add Constantine’s experience to our team as we add new targets to our discovery pipeline and advance our cyclin programs towards the clinic.”

About Circle Pharma, Inc.

Circle is developing a new paradigm for macrocycle drug discovery based on rational design and synthetic chemistry. Circle’s technology facilitates the design and synthesis of intrinsically cell-permeable macrocycles that can address both intra- and extra-cellular therapeutic targets, and can be delivered by oral administration. Circle’s macrocycle development platform is applicable across a wide range of serious diseases; the company is initially focusing its development efforts on intracellular protein-protein interactions that are key drivers in cancer. Its lead programs target cyclins A and E, which are part of the regulatory machinery that controls the progression of cells through the cell growth and division cycle. Inhibition of Cyclin A has been shown to be synthetically lethal in cancers driven by mutations in the Rb pathway. Cyclin E upregulation is associated with resistance to drugs that target cdk4/6 activity and is also found across several cancer types.

Contacts

More information: www.circlepharma.com
Contact: info@circlepharma.com
Eleonor Lim: 650.825.4099

Circle Pharma, Inc.


Release Summary
Circle Pharma hires Constantine Kreatsoulas as its VP of Informatics and Computational Chemistry.
Release Versions

Contacts

More information: www.circlepharma.com
Contact: info@circlepharma.com
Eleonor Lim: 650.825.4099

More News From Circle Pharma, Inc.

Circle Pharma Presents Promising Preclinical Data on First-in-Class Oral Macrocycle Cyclin A/B RxL Inhibitor CID-078 at the San Antonio Breast Cancer Symposium 2024

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Circle Pharma, a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, today announced a poster for preclinical data on CID-078, a first-in-class oral macrocycle cyclin A/B RxL inhibitor, will be presented at the San Antonio Breast Cancer Symposium 2024. The event, which runs from December 10-13, brings together global leaders in breast cancer research and treatment. Poster present...

Circle Pharma’s First-in-Class Oral Macrocycle Cyclin A/B RxL Inhibitor, CID-078, Preclinical Data Highlighted at the 36th EORTC-NCI-AACR Symposium

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Circle Pharma, a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, today announced that preclinical data from its lead candidate, CID-078, a first-in-class oral macrocycle cyclin A/B RxL inhibitor, has been selected for a late-breaking poster presentation at the 36th EORTC-NCI-AACR Symposium on Molecular Targets and Cancer Therapeutics, also known as the Triple Meeting. The sym...

Circle Pharma Announces First Patients Dosed in Phase 1 Clinical Trial of First-in-Class Oral Cyclin A/B RxL Inhibitor CID-078 for Advanced Solid Tumors

SOUTH SAN FRANCISCO, Calif.--(BUSINESS WIRE)--Circle Pharma, Inc., a clinical-stage biopharmaceutical company dedicated to discovering and developing a new generation of macrocycle therapies, announced today that the first patient cohort has been dosed in the phase 1 trial of CID-078, the company’s first-in-class oral cyclin A/B RxL inhibitor. The trial will evaluate CID-078 in patients with advanced solid tumors, including tumors with elevated E2F transcription factor activity, such as small c...
Back to Newsroom