LONDON--(BUSINESS WIRE)--According to the latest market study released by Technavio, the global pulmonary hypertension (PAH) drugs market is projected to grow to USD 4,782.81 million by 2021, at a CAGR of more than 3% over the forecast period.
This research report titled ‘Global Pulmonary Hypertension (PAH) Drugs Market 2017-2021’ provides an in-depth analysis of the market in terms of revenue and emerging market trends. This market research report also includes up to date analysis and forecasts for various market segments and all geographical regions.
| Pulmonary arterial hypertension (PAH) is a condition with a pulmonary vascular resistance that leads to elevated pulmonary arterial pressures, right ventricular failure, and even death in some cases. The introduction of new disease-modifying therapies and agents with high efficacy is expected to boost the growth of the PAH drugs market. |
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Based on the mechanism of action, the report categorizes the global pulmonary hypertension drugs market into the following segments:
- Endothelin receptor antagonists (ERAs)
- Prostacyclin analogs
- Phosphodiesterase (PDE) inhibitors
- Soluble guanylate cyclase (sGC) stimulators
The top three revenue-generating mechanism of action segments in the global pulmonary hypertension drugs market are discussed below:
Endothelin receptor antagonists (ERAs)
“Endothelin receptor antagonists occupied a majority 42% of the global pulmonary arterial hypertension drugs market and is expected to increase its share through the forecast period. The dominance can be attributed to the large number of drugs available in this segment,” says Sapna Jha, a lead analyst at Technavio for cardiovascular and metabolic disorders research.
Endothelin is a peptide naturally prepared in the layer of cells that line the heart and blood vessels. In excess, this peptide acts as a powerful vessel constrictor, and targeted ERA therapy is used to keep the endothelin production in PAH patients at an optimum level to maintain the balance.
Prostacyclin analogs
Prostacyclin analogs are the second most widely preferred mechanism of action, projected to be worth USD 1439.04 million by 2021. Prostacyclin analogs are lipid molecules synthesized by prostacyclin synthase and are involved in platelet activation and vasodilation. These drugs act by direct vasodilation of the pulmonary and systematic arterial vascular beds and also exhibits platelet aggregation and smooth muscle cell proliferation. The rising demand for PAH drugs and inclusion of these drugs in the global bodies’ medical list are expected to drive the growth of the market segment.
Phosphodiesterase (PDE) inhibitors
“There are a limited number of phosphodiesterase inhibitors for the treatment of pulmonary arterial hypertension. Sildenafil and tadalafil are the two approved drugs, which mainly works by releasing nitric oxide to suppress high blood pressure,” says Sapna.
Vendors in the market are also investing in the development of new drugs in this segment, which should drive the market growth. For instance, Novartis is developing QCC374, which is in its Phase II development stage, and more such launches through the next few years will help the market to grow.
The top vendors highlighted by Technavio’s research analysts in this report are:
- Actelion Pharmaceuticals
- DAIICHI SANKYO
- GlaxoSmithKline
- Novartis
- United Therapeutics
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