DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/51db02/advances_in_enzymo) has announced the addition of John Wiley and Sons Ltd's new book "Advances in Enzymology and Related Areas of Molecular Biology, Volume 78" to their offering.
This book covers important advances in enzymology, explaining the behavior of enzymes and how they can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. Advances in Enzymology focuses on enzymes, the primary catalysts of life processes. The explanation of the behavior of enzymes can be found via studies of their chemical mechanisms and can be utilized to develop novel drugs, synthesize known and novel compounds, and understand evolutionary processes. The transglutaminases, first described in 1957, are a large, widely-distributed family of enzymes canonically responsible for the amidation/transamidation of protein side chains. The extraordinary diversity of names associated with various enzymatic activities now recognized and aggregated as transglutaminase bears witness to the remarkable diversity of biological roles associated with the activity, including myriad human diseases.
Key Topics Covered:
- Structure and Regulation of Type 2 Transglutaminase in Relation to Its Physiological Functions and Pathological Roles
- Physiopathological Roles of Human Transglutaminase 2
- Transglutaminase in Epidermis and Neurological Disease or What Makes a Good Cross-Linking Substrate
- Transglutaminase 2: A New Paradigm for NF-B Involvement in Disease
- Transglutaminase 2 At the Crossroads between Cell Death and Survival
- Tissue Transglutaminase and Its Role in Human Cancer Progression
- Transglutaminase 2 Dysfunctions in the Development of Autoimmune Disorders: Celiac Disease and TG2-/-Mouse
- Effects and Analysis of Transglutamination on Protein Aggregation and Clearance in Neurodegenerative Diseases
- Transglutaminase-Mediated Remodeling of the Human Erythrocyte Membrane Skeleton: Relevance for Erythrocyte Diseases with Shortened Cell Lifespan
- Irreversible Inhibitors of Tissue Transglutaminase
- Methionine Adenosyltransferase (S-Adenosylmethionine Synthetase)
Author:
Eric J. Toone, PhD, is Professor of Chemistry and Professor of Biochemistry at Duke University. He holds numerous patents and has written extensively on physical organic and biophysical chemistry. Professor Toone is the Deputy Director for the Advanced Research Projects AgencyEnergy (ARPA-E) of the Department of Energy and directs ARPA-E's electrofuels program.
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