DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/46fe2a/purinergic_signall) has announced the addition of John Wiley and Sons Ltd's new book "Purinergic Signalling in Neuron-Glia Interactions, No. 276" to their offering.
ATP, the intracellular energy source, is an extremely important cell-cell signalling molecule for a wide variety of cells across evolutionarily diverse organisms. The extracellular biochemistry of ATP and its derivatives is complex, and the large number of membrane receptors that they activate are linked to many intracellular signalling systems.
Purinergic signalling affects a diverse range of cellular phenomena, including ion channel function, cytoskeletal dynamics, gene expression, secretion, cell proliferation, differentiation and cell death. Recently, this class of signalling molecules and receptors has been found to mediate communication between neurons and non-neuronal cells (glia) in the central and peripheral nervous systems. Glia are critical for normal brain function, development and response to injury.
It is now clear that neural impulse activity is detected by glia and purinergic signalling is emerging as a major means of integrating functional activity between neurons, glia and vascular cells in the nervous system. These interactions mediate effects of neural activity on development of the nervous system and in association with injury, neurodegeneration, myelination and cancer.
This book brings together contributions from experts in several fields, including glial biologists, neurobiologists and specialists in purinergic receptor structure and pharmacology, to consider how extracellular ATP acts to integrate communication between different types of glia, and between neurons and glia. It opens with overviews of the evolution and differentiation of glia and of purinergic signalling, and continues with detailed coverage of purine release, receptors and reagents, purinergic signalling in the neural control of glial development, glial involvement in information processing, and discussion of the interactions between neurons and microglia.
Key Topics Covered Include the Following:
- Kristjan R. Jessen A brief look at glial cells
- Bernard Zalc The acquisition of myelin: a success story
- Geoffrey Burnstock Purinergic signallingan overview
- General discussion I
- Kenneth A. Jacobson, Stefano Costanzi, Bhalchandra V. Joshi, Pedro Besada, Dae Hong Shin, Hyojin Ko, Andrei Ivanov and Liaman Mamedova Agonists and antagonists for P2 receptors
- Eduardo Lazarowski Regulated release of nucleotides and UDP sugars from astrocytoma cells
- Maria P. Abbracchio and Claudia Verderio Pathophysiological roles of P2 receptors in glial cells
- General discussion II
- Herbert Zimmermann ectonucleotidases in the nervous system
- Joseph T. Neary, Yuan Kang, You-fang Shi, Minh D. Tran and Ina B. Wanner P2 receptor signalling, proliferation of astrocytes, and expression of molecules involved in cellcell interactions
- R. Douglas Fields nerve impulses regulate myelination through purinergic signalling
- Beth Stevens Cross-talk between growth factor and purinergic signalling regulates Schwann cell proliferation
- Freddy Jeanneteau and Moses V. Chao Promoting neurotrophic effects by GPCR ligands
- Eric A. Newman A purinergic dialogue between glia and neurons in the retina
- Tommaso Fellin, Jai-Yoon Sul, Marcello DAscenzo, Hajime Takano, Olivier Pascual and Philip G. Haydon Bidirectional astrocyteneuron communication: the many roles of glutamate and ATP
- Keith J. Todd and Richard Robitaille neuronglia interactions at the neuromuscular synapse
- General discussion III
- Stphane H.R. Oliet, Aude Panatier and Richard Piet Functional neuronalglial anatomical remodelling in the hypothalamus
- Francesco Di Virgilio Purinergic signalling between axons and microglia
- Kazuhide Inoue ATP receptors of microglia involved in pain
For more information visit http://www.researchandmarkets.com/research/46fe2a/purinergic_signall