IRVINE, Calif.--(BUSINESS WIRE)--Fondation IPSEN (Boulogne-Billacourt, France), INSERM (French National Institute of health and Medical research, France) and the Center for Epigenetics and Metabolism (CEM) of University of California Irvine (UCI) are pleased to announce a new series of meetings starting in 2016: “Epigenetic Control and Cellular Plasticity”. This year’s meeting, held at the Beckman Center of the National Academy of Sciences (Irvine, USA) on October 6 and 7, continues the tradition of high profile conferences organized by the CEM, headed by Paolo Sassone-Corsi. Today we bring together leaders in the field of epigenetics and metabolism at this symposium and we invite you all to discover the multiple facets of this field that connects molecular medicine, pharmacology and therapeutics.
Few words on Epigenetics
The ability to store information over long
periods of time lies at the heart of cellular identity. This cellular
‘memory’ is encoded in the specific pattern of expressed genes and
allows a cell to ensure that it “remembers” what it is and how it should
move along elaborate pathways during cellular development and
differentiation. As an example, nerve cells become hard-wired during
their differentiation, through changes that allow them to properly
control cognitive and behavioral functions. How could one relatively
fixed genetic blueprint permit flexibility to accommodate variability
resulting from signals originated from environmental, dietary and other
influences?
Cells are submitted to an exceptional variety of
stimuli and are able to convert these into complex functions and
modulated metabolism. These unique properties are based on the highly
flexible nature of the genome, a characteristic that relies on the
complex molecular machinery that controls gene expression. What lies at
the heart of cellular plasticity? Today we know about the central role
played by epigenetics. This word originally indicated potentially
heritable modifications in gene expression that do not involve changes
in DNA sequence. During the past decade this definition has acquired a
much less strict significance, and epigenetic control is thought to
include DNA methylation, histone modifications, histone variants,
microRNA metabolic pathways and non-histone proteins modifications.
Thus, while cellular plasticity is rightly thought to be intimately
associated with genomic control, it is evident that there is much more
to the genome than DNA sequence, permitting variability beyond the
Watson-Crick double helix. The multitude of epigenetic mechanisms
operating in all cells begs the question of how these may be coordinated
and how specificity is achieved.
Recent years have seen spectacular
advances in the study of epigenetics, attracting researchers from a
variety of fields. In the upcoming decade, many aspects of biological
research, pharmacological strategies and therapeutic applications will
be dominated by deciphering the mechanisms of epigenetic control. The
CEM of the School of Medicine at UCI traditionally organizes Symposia on
“Epigenetic Control of Cellular Plasticity” to bring together
international leaders to discuss most recent developments and exciting
new directions. This year’s Symposium is organized together with the
INSERM, whose research Unit 904 operates within UCI, and the Fondation
IPSEN.
Invited speakers & Talk titles
Yang SHI (Department
of Cell Biology, Harvard Medical School, Boston, USA)
Histone methylation regulation, recognition and link to human disease
Robert G. ROEDER (Laboratory of Biochemistry and Molecular Biology, The Rockefeller University, New York, USA)
Mechanistic Studies of the Cooperative Functions of Transcriptional Co-activators on Chromatin Templates
Asifa AKHTAR (Max Planck Institute of Immunobiology and Epigenetics, Freiburg, Germany)
Epigenetic regulation by MOF containing complexes
Paolo SASSONE-CORSI (U904 INSERM, Center for Epigenetics and Metabolism, UCI, USA)
The circadian clock: linking metabolism to epigenetics
John DENU (Department of Biomolecular Chemistry, Wisconsin Institute for Discovery, Madison, USA)
Gut microbiota and host epigenetic programming
Leonard P. GUARENTE (Glenn Labs for the Science of Aging, MIT, Cambridge, USA)
Sirtuins, NAD and Stem cells
Juleen ZIERATH (Department of Molecular Medicine and Department of Physiology and Pharmacology, Section of Integrative Physiology, Karolinska Institutet, Stockholm, Sweden)
The role of diet and exercise in modifying the epigenetic landscape of Type 2 diabetes
Melanie OTT (Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA)
Epigenetic regulation of HIV Transcription
Eric SOLARY (INSERM U1170 Hématopoïèse normale et pathologique, Institut Gustave Roussy, Villejuif, France)
Hypomethylating agents improve disease phenotype without decreasing genetic alteration burden in chronic myelomonocytic leukemia
Gerald R. CRABTREE (Howard Hughes Medical Institute, Beckman Center, Stanford, USA)
Balancing Genomic Accessibility by BAF-Polycomb Opposition
Anne SCHAEFER (Department of Neurosciences, Mount Sinai School of Medicine, New York, USA)
Polycomb repressive complex 2 (PRC2) protects neurons against neurodegeneration
Marcelo WOOD (Department of Neurobiology and Behavior, University of California, Irvine, USA)
Investigating the role of BAF53b in associative memory processes
Eric VERDIN (Gladstone Institute of Virology and Immunology, University of California, San Francisco, USA)
Longevity and healthspan effects of ketogenic diet in mice
Valerio ORLANDO (Biological and Environmental Science and Engineering Division, KAUST, Thuwal, KSA)
Role of Polycomb cell memory system in circadian clock and adaptation to metabolic stress in mammalian skeletal muscle.
Salvador A. BENITAH (Institute for Research in Biomedicine, Barcelona Institute of Science and Technology, Barcelona, Spain)
Adult stem cells undergo diet-dependent circadian reprogramming during ageing
The Fondation IPSEN
Established in 1983 under the aegis of the
Fondation de France, the ambition of the Fondation IPSEN is to initiate
a reflection about the major scientific issues of the forthcoming years.
The long-standing mission of the Fondation IPSEN is to contribute to the
development and dissemination of scientific knowledge by fostering
interaction between scientists and clinicians. It has developed an
important international network of scientific experts who meet regularly
at meetings known as Colloques Médecine et Recherche, dedicated to three
main topics: neurosciences, endocrinology and cancer science. Moreover
the Fondation IPSEN has started several series of meetings in
partnership with the Salk Institute, the Karolinska Institute as well as
with the science journals Cell and Science. The Fondation IPSEN produced
several hundred publications and more than 250 scientists have been
awarded prizes and grants. (more informations on: www.fondation-ipsen.org).
The Center for Epigenetics and Metabolism (UCI, Irvine)
The Center
for Epigenetics and Metabolism (CEM), headed by Paolo Sassone-Corsi, at
UC Irvine School of Medicine provides a physical, intellectual and
organizational environment for the study of epigenetics and its
relationship with cellular metabolism. The center fosters collaboration
among researchers interested in epigenetics, chromatin remodeling and
cellular metabolism (more informations on: http://www.som.uci.edu/cem/index.asp).
INSERM
Founded in 1964, INSERM is a public scientific and
technological institute which operates under the joint authority of the
French Ministry of Health and French Ministry of Research. As the only
French public research institute to focus entirely on human health, in
2008 INSERM took on the responsibility for the strategic, scientific and
operational coordination of biomedical research. This key role as
coordinator comes naturally to Inserm thanks to the scientific quality
of its teams and its ability to conduct translational research, from the
laboratory to the patient’s bed. The decree adopted in March 2009 will
enable INSERM to perform its research missions in the face of the new
scientific, health and economic challenges of the 21st
century (more informations on: www.inserm.fr).
Further information can be obtained by visiting:
http://www.som.uci.edu/cem/epigenetics-symposium/index.asp
https://www.youtube.com/watch?v=1-dUDkg6TEU