DUBLIN--(BUSINESS WIRE)--Research and Markets (http://www.researchandmarkets.com/research/43af8d/update_on_polymers) has announced the addition of iSmithers Publishing 's new book "Update on Polymers for Ocular Drug Delivery" to their offering.
The eye is the most easily accessible site for topical administration of a medication. Drugs are commonly applied to the eye for localised action on the surface or in the interior of the eye. A major problem in ocular therapeutics is the attainment of an optimal drug concentration at the site of action. Poor bioavailability of drugs from ocular dosage forms is mainly due to the precorneal loss factors which include tear dynamics, non-productive absorption, transient residence time in the cul-de-sac, and the relative impermeability of the corneal epithelial membrane. Due to these physiological and anatomical constraints only a small fraction of the drug, effectively 1% or even less of the instilled dose is ocularly absorbed.
The effective dose of medication administered ophthalmically may be altered by increasing the retention time of medication in contact with the surface of the eye. To date, Pharmaceutical Technologists have tried to develop different novel formulations like gel, ocular inserts, collagen shields, implants, liposomes, nanoparticles, penetration enhancers and in-situ gelling systems, in order to increase the bioavailability and duration of the therapeutic action of ocular drugs and polymers plays an important role in all these approaches.
This book provides detailed information regarding all such polymers which have been used and shown to be excellent in improving the bioavailability of ocular drugs.
Key Topics Covered:
1 Introduction: Overview of Ocular Drug Delivery
1.1 Drug Delivery and Polymer Science
1.2 Ocular Drug Delivery
2 Conventional Ocular Drug Delivery
2.1 Introduction
2.2 Eye Drops
2.3 Semisolids
2.4 Summary and Conclusion
3 Hydrogels and Viscosity Modifiers
3.1 Introduction
3.2 Hydrogels
3.3 Viscosity Enhancing Agents
3.4 Summary and Conclusion
4 Ocular Inserts.
4.1 Introduction
4.2 Ocular Inserts as Drug Delivery Systems
4.3 Summary and Conclusion
5 Particulate Drug Delivery
5.1 Introduction
5.2 Nanoparticles and Polymers used in their Preparation
5.3 Microparticles and Polymers used in their Preparation
5.4 Summary and Conclusion
6 In Situ Gelling Polymers in Ocular Drug Delivery
6.1 Introduction
6.2 In Situ Gelling Hydrogels
6.3 Summary and Conclusion
7 Intraocular Implants
7.1 Introduction
7.2 Polymers used for Intraocular Drug Delivery Implants
7.3 Summary and Conclusion
7.4 Future Directions for Ophthalmic Research
For more information visit http://www.researchandmarkets.com/research/43af8d/update_on_polymers